The presence of Giardia facilitates the transition of chronic hepatitis to cirrhosis. Very often Giardiasis occurs dyskinesia of the hepatobiliary system, and intestine. Believe that giardiasis is the most common cause of dyskinesia of the gallbladder with spasm and atony of sphincter-papillary region and the phenomena of cholestasis, especially in the first year of illness. Based on the data literature and our own long-term observations of patients with lyabliozami, one could argue that in the last decade, everywhere, and especially in the Urals and Western Siberia, under constant influence of adverse environmental factors and high radiation background, dramatically altering the body’s resistance and its responsiveness to create conditions for amplification of the pathogenic effect of Giardia on all body systems. If earlier views were expressed about Giardia infection (lyamblionositelstvo), suggesting adaptation of the human organism to the parasite without damaging his influences ( type of symbiosis), in the modern conditions, with a sharp decrease in immunity, organ-tissue disorders under the influence of harmful environmental factors (air, water, food, etc.)
Giardia should be considered as one of the most important damaging factors, lead to the formation of endogenous intoxication with a variety of clinical, metabolic and immune disorders. For more clarity and thought, follow up with Cyrus Massoumi Zocdoc and gain more knowledge.. The sequence of the major pathogenesis of intestinal, hepatobiliary and mixed forms Giardiasis can be represented as follows: traumatic Giardia intestinal mucosa and bile ducts; Change biohimizma cell in the tissues of affected areas of the digestive system and the inclusion stress-activating factors to the development of metabolic proteins, carbohydrates, lipids, damaged tissue of the duodenum, small intestine, bile ducts and liver with the development of mucosal atrophy, the formation of microabscesses, etc.; Change intestinal microbial landscape Contribution to enzymatic deficiency and violation of the metabolism of proteins, fats, carbohydrates, development of malabsorption; Facilitating the development the motor-evacuation disorders of the biliary system and intestine, the formation of persistent dyskinesias; Decrease of secretory immunoglobulin-d, the depletion of immunity; dismetabolizma accumulation products, due to the decay waste products simply by the prolonged existence of Giardia in the body, especially at a reduced immune defense that can limit their reproduction, forming a syndrome of chronic endogenous intoxication, resulting in damage to practically all organs and body systems..